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- The PHERGuide study demonstrates the utility of circulating tumor DNA for the early detection and re...
The results of the PHERGuide study, presented during the 2025 San Antonio Breast Cancer Symposium (SABCS), demonstrate that the presence of circulating tumor DNA (ctDNA) is associated with disease stage.This research paves the way for the use of blood-based ctDNA… ...[TheTopNews] Read More.6 days ago - Why Indiana Republicans Are Standing Up to Trump
The Indiana legislature does not keep its constituents at a great distance. As lawmakers convened in Indianapolis on Monday to consider a bill backed by President Donald Trump to redraw the state’s congressional map, all that separated them from protesters who had gathered in a corridor just outside the capitol chamber was a series of glass windows. Inside the room, chants of “Just vote no!” and “We want fair maps!” could be heard as clearly as the legislative debate.In an era when politicians typically operate at arm’s length from their voters, the public’s easy access to elected representatives is refreshing. In Indiana this week, it’s also a bit jarring. The state Senate is meeting under threat. Trump and his allies have vowed to target Republican lawmakers who vote against a redistricting plan that could wipe out the state’s Democratic congressional representation, protecting the U.S. House GOP majority. Over the past… ...[TheTopNews] Read More.6 days ago - Sperm donor with hidden cancer gene fathers nearly 200 kids, families blindsided
A sperm donor whose samples helped conceive nearly 200 children across Europe unknowingly carried a cancer-causing genetic mutation — a hidden risk now tied to multiple childhood illnesses and early deaths.An investigation led by the BBC and multiple other public service broadcasters revealed that the donations were made to Denmark's European Sperm Bank (ESB), and it was then used by 67 fertility clinics in 14 countries over a 17-year span.The donor, who was not identified, was paid to donate as a student beginning in 2005, according to the report.ROBOTS POWER BREAKTHROUGH IN PREGNANCY RESEARCH, BOOSTING IVF SUCCESS RATESAlthough the donor passed the initial health screenings, he had hidden genetic mutations that damaged the TP53 gene, which helps to prevent cancer by repairing DNA damage or trigger the death of cancer cells.When TP53 is mutated, those protective functions are lost, which can lead to uncontrolled cell division, accumulation of mutations and… ...[TheTopNews] Read More.6 days ago - Large Fleet Closings Dominate Headlines, But Small Fleets Face the Biggest
The trucking industry continues to struggle through a prolonged freight downturn, and despite major headlines about large carriers shutting down, it’s the small trucking fleets that have the most to worry about. While small operators survived longer than many expected—thanks to low overhead, COVID-era financial cushions, and smarter use of technology—new regulatory crackdowns may push many of them out of the market. Why Small Fleets Survived — Until Now Industry analysts say small trucking companies managed to stay afloat even as freight rates dropped sharply. Avery Vise, VP of trucking at FTR Transportation Intelligence, notes several reasons: Pandemic stimulus funds helped sustain small businesses. Many owner-operators paid off equipment or reduced debt during the high-rate years of 2021. Small fleets operate with limited overhead—no large offices, support staff, or expensive infrastructure. Technology helped improve equipment utilization, allowing them to stay profitable even when rates… ...[TheTopNews] Read More.6 days ago - Massachusetts man diagnosed with deadly lung disease linked to popular kitchen countertopsMassachusetts health officials announced Tuesday that the state has confirmed its first case of an incurable lung disease linked to exposure to certain countertop stones.The disease is particularly associated with quartz, which has become increasingly popular in recent years for its practicality and aesthetic, according to health officials.The Massachusetts Department of Public Health (DPH) said a 40-year-old man, who has worked in the stone countertop industry for 14 years, was recently diagnosed with silicosis, a condition that can cause death. "The confirmation of this case in Massachusetts is a tragic reminder that silicosis is not just a distant threat. It is here, and it is seriously impacting the health of workers in Massachusetts," Emily H. Sparer-Fine, a director at DPH, said in a statement.MICHIGAN MAN DIES OF RABIES AFTER RECEIVING KIDNEY FROM INFECTED DONOR WHO SAVED KITTEN FROM SKUNK: CDCThe unnamed patient reportedly performed activities such as cutting, grinding and polishing,… ...[TheTopNews] Read More.7 days ago
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The results of the PHERGuide study, presented during the 2025 San Antonio Breast Cancer Symposium (SABCS), demonstrate that the presence of circulating tumor DNA (ctDNA) is associated with disease stage.This research paves the way for the use of blood-based ctDNA… ...[TheTopNews] Read More.
6 days ago
The Indiana legislature does not keep its constituents at a great distance. As lawmakers convened in Indianapolis on Monday to consider a bill backed by President Donald Trump to redraw the state’s congressional map, all that separated them from protesters who had gathered in a corridor just outside the capitol chamber was a series of glass windows. Inside the room, chants of “Just vote no!” and “We want fair maps!” could be heard as clearly as the legislative debate.In an era when politicians typically operate at arm’s length from their voters, the public’s easy access to elected representatives is refreshing. In Indiana this week, it’s also a bit jarring. The state Senate is meeting under threat. Trump and his allies have vowed to target Republican lawmakers who vote against a redistricting plan that could wipe out the state’s Democratic congressional representation, protecting the U.S. House GOP majority. Over the past… ...[TheTopNews] Read More.
6 days ago
A sperm donor whose samples helped conceive nearly 200 children across Europe unknowingly carried a cancer-causing genetic mutation — a hidden risk now tied to multiple childhood illnesses and early deaths.An investigation led by the BBC and multiple other public service broadcasters revealed that the donations were made to Denmark's European Sperm Bank (ESB), and it was then used by 67 fertility clinics in 14 countries over a 17-year span.The donor, who was not identified, was paid to donate as a student beginning in 2005, according to the report.ROBOTS POWER BREAKTHROUGH IN PREGNANCY RESEARCH, BOOSTING IVF SUCCESS RATESAlthough the donor passed the initial health screenings, he had hidden genetic mutations that damaged the TP53 gene, which helps to prevent cancer by repairing DNA damage or trigger the death of cancer cells.When TP53 is mutated, those protective functions are lost, which can lead to uncontrolled cell division, accumulation of mutations and… ...[TheTopNews] Read More.
6 days ago
The trucking industry continues to struggle through a prolonged freight downturn, and despite major headlines about large carriers shutting down, it’s the small trucking fleets that have the most to worry about. While small operators survived longer than many expected—thanks to low overhead, COVID-era financial cushions, and smarter use of technology—new regulatory crackdowns may push many of them out of the market. Why Small Fleets Survived — Until Now Industry analysts say small trucking companies managed to stay afloat even as freight rates dropped sharply. Avery Vise, VP of trucking at FTR Transportation Intelligence, notes several reasons: Pandemic stimulus funds helped sustain small businesses. Many owner-operators paid off equipment or reduced debt during the high-rate years of 2021. Small fleets operate with limited overhead—no large offices, support staff, or expensive infrastructure. Technology helped improve equipment utilization, allowing them to stay profitable even when rates… ...[TheTopNews] Read More.
6 days ago
Massachusetts health officials announced Tuesday that the state has confirmed its first case of an incurable lung disease linked to exposure to certain countertop stones.The disease is particularly associated with quartz, which has become increasingly popular in recent years for its practicality and aesthetic, according to health officials.The Massachusetts Department of Public Health (DPH) said a 40-year-old man, who has worked in the stone countertop industry for 14 years, was recently diagnosed with silicosis, a condition that can cause death. "The confirmation of this case in Massachusetts is a tragic reminder that silicosis is not just a distant threat. It is here, and it is seriously impacting the health of workers in Massachusetts," Emily H. Sparer-Fine, a director at DPH, said in a statement.MICHIGAN MAN DIES OF RABIES AFTER RECEIVING KIDNEY FROM INFECTED DONOR WHO SAVED KITTEN FROM SKUNK: CDCThe unnamed patient reportedly performed activities such as cutting, grinding and polishing,… ...[TheTopNews] Read More.
7 days ago
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