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- Experimental pill could change treatment for advanced pancreatic cancer
Large clinical trial finds targeted therapy helped patients live longer than chemotherapy By Kristen Dalli of ConsumerAffairs June 26, 2026 An experimental targeted drug nearly doubled median survival for people with previously treated metastatic pancreatic cancer.The phase three clinical trial compared the daily pill with standard chemotherapy in nearly 500 patients worldwide.Researchers say the findings could lead to a new treatment option for patients with few effective alternatives.Pancreatic cancer is one of the most difficult cancers to treat, especially after it has spread to other parts of the body and stopped responding to initial therapy. For many patients in that situation, treatment options are limited and survival has historically remained short. Now, a large international clinical trial is offering new hope with an experimental targeted drug that significantly outperformed standard chemotherapy. The medication, called daraxonrasib, works differently from traditional chemotherapy. Instead of attacking rapidly growing cells, it targets the RAS signaling pathway, which drives the growth of more than 90% of pancreatic cancers. According to researchers, the study marks the first time a phase three trial has shown such a substantial survival benefit over chemotherapy for patients with previously treated metastatic pancreatic cancer. For years weve made incremental gains in treating pancreatic cancer, researcher Dr. Zev Wainberg said in a news release. Now, for the first time, we have demonstrated that targeted inhibition of RAS using an oral inhibitor is changing the landscape of this terrible disease. Seeing this magnitude of benefit in a randomized phase three study is very encouraging for all patients with advanced pancreatic cancer and is a paradigm shift in this deadly disease.The studyThe phase three trial enrolled 479 adults with metastatic pancreatic ductal adenocarcinoma whose cancer had continued growing after one previous course of chemotherapy. Participants were randomly assigned to receive either a 300-milligram daily dose of daraxonrasib or one of several commonly used chemotherapy treatments selected by their physician.Researchers followed patients to compare how long they lived overall, how long their cancer remained under control, how their tumors responded to treatment, and how the therapies affected quality of life. They also monitored side effects throughout the study. Because the trial randomly assigned participants to one treatment or the other, researchers were able to directly compare outcomes between the two groups. The resultsThe results were striking. Patients who received daraxonrasib had a median overall survival of 13.2 months, compared with 6.7 months for those treated… [TheTopNews] Read More.3 days ago - The hardest places in America to insure a homeA new home insurance risk index reveals which U.S. counties face the biggest insurance challenges By Kristen Dalli of ConsumerAffairs June 26, 2026 A new Insurify analysis found that Florida, Louisiana, and North Carolina are home to many of the nation's least insurable counties, where homeowners face the highest insurance costs and risks.The rankings are based on factors including natural disaster risk, home age, property values, and local insurance premiums, all of which influence how expensive and difficult it is to insure a home.Experts say homeowners can help lower their insurance costs by weather-proofing their homes, shopping around for coverage regularly, and asking insurers about available discounts.Home insurance has become more expensive and in some parts of the country, it's also becoming much harder to get. As extreme weather events grow more frequent and costly, insurers are raising rates, limiting coverage, or pulling out of high-risk areas altogether. A new home insurance risk index from Insurify highlights the counties where homeowners are facing the greatest insurance burden, with many of the hardest-hit areas concentrated in Florida, Louisiana, and North Carolina.To better understand what's driving these trends and what they could mean for homeowners, ConsumerAffairs spoke with Insurify Senior Economic Analyst Matt Brannon about why some counties are becoming increasingly difficult to insure and how climate risk is reshaping the home insurance market.Identifying riskInsurify's Home Insurance Risk Index scored more than 3,100 U.S. counties based on factors that influence how difficult and expensive it is to insure a home. First we look at natural-hazard and extreme-weather risk, Brannon said. Counties with more vulnerability to natural disasters (e.g., wildfires, earthquakes, flooding, hail, etc.) are more prone to frequent and costly insurance claims. The second factor assessed is the age of a county's housing stock. Because of outdated building codes, worn-down materials, and a lack of regular upkeep, older properties are more susceptible to damage from severe weather. We also look at the number of residential structures in a county and the ratio of residential to commercial structures. Additionally, we examine the countys median home value, as insurers generally charge higher premiums for more expensive homes, since they are more costly for the insurer to afford to replace. Finally, we incorporated average annual home insurance premiums by county, which capture risk factors that physical hazard models dont fully reflect. Factors like local litigation and claims environments, crime rates, rebuilding cost inflation, and insurance… [TheTopNews] Read More.3 days ago
- GLP-1 use can skyrocket with new pill form, stressing grocery industry
Adoption continues to rise with 13.1% of adults using in June 2026 [TheTopNews] Read More.3 days ago - Court rejects’ Albertsons bid for Kroger legal documentsLatest ruling shields lawyers’ internal deliberations over antitrust divestitures [TheTopNews] Read More.3 days ago
- Piggly Wiggly Midwest brings dairy to lifeNew campaign focuses on the milk producers, not the products [TheTopNews] Read More.3 days ago
- Wakefern celebrates America’s 250th through packaging, special offersGrocer launches Star-Spangled Own Brands initiative [TheTopNews] Read More.3 days ago
- America’s most stressful states for drivers — and how to make your commu...The states where driving is most frustrating, with California leading the way By Kyle James of ConsumerAffairs June 26, 2026 California ranks No. 1: Heavy traffic, long commutes, and poor roads make it America's most stressful state for drivers.Stress goes beyond traffic: Crashes, potholes, aggressive drivers, bad weather, and costly repairs all add to the daily commute.Drive smarter: Leave early, use navigation apps, keep up with maintenance, and consider a dash cam or adaptive cruise control.If it feels like driving has become more stressful lately, you're not imagining it.A new study from Nicolet Law ranked the states where driving is most stressful, looking at everything from traffic congestion and commute times to road conditions, crash rates, and even weather-related disruptions.The results may not surprise many drivers. California topped the list as the most stressful state for motorists, followed by Mississippi, Texas, Louisiana, and New Jersey.Researchers found that California roads carry nearly 20,000 vehicles per lane each day far more than most states. Drivers also contend with long commutes and some of the country's worst road conditions.Mississippi ranked second, largely because it had the highest fatal crash rate in the nation. Texas came in third due to a combination of dangerous weather, heavy traffic, and above-average crash rates.Meanwhile, New Jersey earned a spot in the top five thanks to the longest average commute times in the country, with many workers spending more than an hour each day traveling to and from work.Why driving feels more stressfulTraffic is only part of the problem. Many drivers are dealing with the following factors that can make every trip more frustrating:Congested roadsAggressive drivingRising repair costsPotholes and poor pavementLonger commutesWeather-related delaysIncreased accident risksEven short daily trips can feel slightly mentally draining when you repeatedly face crowded roads that are in poor condition.And that is not to mention the possible financial impacts. Poor road conditions can contribute to tire damage, suspension repairs, wheel alignments, and other costly vehicle maintenance issues.How drivers can reduce stress behind the wheelWhile you can't eliminate traffic, there are several ways to make driving safer and less stressful.Give yourself extra time: One of the biggest causes of driving stress is feeling rushed. Leaving just 10 to 15 minutes earlier can reduce the temptation to speed, weave through traffic, or make risky decisions.Use navigation apps even on familiar routes: Apps like Google Maps and Waze can alert you to accidents, construction zones, road closures,… [TheTopNews] Read More.3 days ago
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