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- Rollout of Covid vaccines extraordinary feat – inquiry report
Covid vaccines saved hundreds of thousands of lives, but small minority harmed need better support, says report. [TheTopNews] Read More.32 mins ago - Covid jabs huge success, but work needed on trust in vaccines – key findin...Immunisation saved hundreds of thousands of UK lives, but vaccine hesitancy remains an issue. [TheTopNews] Read More.2 hours ago
- What is the UK Covid inquiry and how does it work?The fourth report from the inquiry into the pandemic said the vaccine roll-out was an "extraordinary feat". [TheTopNews] Read More.4 hours ago
- This could be why your weight-loss medication isn’t delivering results
The skyrocketing popularity of GLP-1 receptor agonists has transformed the weight-loss industry, but not all shots are created equal in terms of how they work.A study published in Nature investigated how genes affect the success of modern weight-loss drugs — specifically, GLP-1s like semaglutide and tirzepatide.In analyzing genetic data and self-reported weight loss from over 27,000 users, researchers pinpointed a specific variation in the GLP-1 receptor gene (GLP1R) that acts as a "booster" for the drug’s effectiveness.POPULAR WEIGHT-LOSS MEDICATIONS LINKED TO HIDDEN SIDE EFFECTS, STUDY FINDSIndividuals carrying one copy of this variant lost an average of 1.6 pounds more than those without it, according to the findings.This suggests that genetic testing could eventually help doctors steer sensitive patients toward medications they are more likely to tolerate."We believe these reports are a step forward in meeting an unmet need for a more informed and personalized approach to weight management," said study co-author Noura Abul-Husn, chief medical officer at the 23andMe Research Institute in California, in a press release.While this genetic "boost" is measurable, it remains relatively modest when compared to the total average weight loss of 24 pounds observed across the study population, the researchers noted.SHOULD YOU MICRODOSE OZEMPIC? EXPERTS ARE SPLIT ON RISKS VS BENEFITSBeyond genetics, other factors such as age, sex and specific medications remain much stronger predictors of success.For instance, the study found that women generally saw a higher body mass index (BMI) reduction (12.2%) compared to men (10.0%).The study may also reveal why certain patients experience stomach issues. Scientists identified a different genetic variant that was linked to increased reports of nausea and vomiting.The presence of this side effect did not impact the drug's effectiveness, however. Patients with variants in the GLP1R and GIPR genes lost just as much weight as those without it; they simply felt more sick during the process, the study found.WEIGHT-LOSS MEDICATIONS COULD IMPACT SEXUAL HEALTH IN UNEXPECTED WAYS"GLP-1 treatment decisions are complex, and having access to clinical expertise to help contextualize your genetic results alongside your full health picture is exactly the kind of guidance this report is designed to support," said Abul-Husn.Dr. Peter Balazs, MD, a hormone and weight-loss specialist serving the New York and New Jersey area, was not involved in the study but reiterated the role of the genetic variants in treatment response and side effects.CLICK HERE FOR MORE HEALTH STORIES"Notably, there appears to be a drug-specific effect: The GIPR variant associated… [TheTopNews] Read More.4 hours ago - NHS tracker – are hospital waiting times improving near you?Use our interactive tracker to see if treatment waits are getting better at your local hospital. [TheTopNews] Read More.5 hours ago
- ‘Breakthrough’ Alzheimer’s drugs unlikely to benefit patients,...A major review has provoked a backlash after concluding the medicines provide too little benefit to be noticed. [TheTopNews] Read More.9 hours ago
- I feared my son had a brain tumour but he’d been poisoned with vitamin DInvestigations found Roo had been accidentally poisoned with a dose of vitamin D prescribed for growing pains. [TheTopNews] Read More.10 hours ago
- Wellbeing garden opens to combat isolationThe outdoor area at Yarm Wellness will officially open to the public on Saturday. [TheTopNews] Read More.10 hours ago
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