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- Experimental Alzheimer’s drug could reduce alcohol withdrawal damage, research...
An investigational dementia drug may also ease alcohol withdrawal by calming the brain inflammation linked to addiction and relapse.That’s according to researchers at the University of Kentucky, who studied an experimental medication called MW150 that targets a brain inflammation pathway known as p38α MAPK.The drug, which has not yet been approved, is designed to treat mild to moderate Alzheimer’s disease.ALCOHOL DEATHS HAVE MORE THAN DOUBLED IN RECENT YEARS, ESPECIALLY AMONG WOMENScientists believe neuroinflammation may contribute to relapse risk and long-term neurological damage in people with alcohol use disorder.In laboratory and animal-model experiments, MW150 was found to reduce certain inflammatory markers during alcohol withdrawal.The work, which was published in the journal Alcohol, came from the University of Kentucky’s Sanders-Brown Center on Aging, led by neuroinflammation researcher Linda Van Eldik.ALCOHOL POSES THESE 8 RISKS TO OLDER ADULTS, EXPERTS WARNCaleb Bailey, PhD, co-author of the study and a researcher in Van Eldik’s lab, said the study provides "biological plausibility" that MW150 could mitigate neuroinflammation arising from alcohol withdrawal.Alcohol use disorder is difficult to treat because of high relapse rates, especially during withdrawal, according to Bailey."If follow-up experiments reveal similar anti-inflammatory effects of MW150 in animal models of alcohol use disorder, it would provide a strong rationale for development of MW150 as a treatment for those struggling with chronic alcohol relapse due to alcohol withdrawal," he told Fox News Digital.'I"M A NEUROSURGEON — HERE'S WHAT ALCOHOL DOES TO THE BODY'MW150, along with a related drug called Neflamapimod, is already being investigated in clinical trials as a potential therapy for dementia and other neurodegenerative conditions, the researchers noted."That gives this work added significance," Bailey said. "Because these compounds are already further along in development for other neurological diseases, it raises the possibility that they could someday be repurposed more efficiently for alcohol-related conditions if future studies continue to show promise."CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTERThere were some important caveats of the research, including that it was conducted in cell culture and animal models."Because they are ‘dish’-based models, they provide limited information regarding what happens in the full organism – or even the full brain for that matter," Bailey said."A series of follow-up studies in living animals is required to more fully understand how future MW150 treatment in alcohol use and withdrawal affects systemic health and/or alcohol consumption."CLICK HERE FOR MORE HEALTH STORIESDr. Amy Swift, deputy chief medical officer at Silver Hill Hospital… [TheTopNews] Read More.4 days ago - Filtered water at specific ages could add months to your lifespan decades later,...Drinking filtered water may extend a person's life by several months, according to a new study.The research, published in the American Journal of Health Economics, reveals that being exposed to water filtration systems early in life can significantly increase longevity. By analyzing public health infrastructure shifts from the early 20th century, researchers found that city water filtration alone increased the lifespan of older American men by an average of 3.2 months.UPGRADE YOUR TAP WITH THESE COUNTERTOP REVERSE OSMOSIS SYSTEMS"While water quality has improved in many areas, this study shows the real impacts to communities without access to safe water, both in the U.S. and globally," co-author Jason Fletcher, a professor at the University of Wisconsin–Madison, said in a press release."The consequences on human health are significant."The team analyzed data from the Social Security Administration’s Death Master Files. They tracked death records for American men born between 1975 and 2005, mapping each individual’s year and city of birth to historical water filtration records.WHERE YOU LIVE COULD SHAPE YOUR RISK OF CANCER MORTALITY, STUDY SUGGESTSBy connecting early-life environments to late-life outcomes, the researchers isolated the lifelong impact of clean water.CLICK HERE FOR MORE HEALTH STORIESBeyond adding months to a person's life, the study suggests that clean water in childhood sets off a positive chain reaction for socioeconomic and physical development.Additional data from mid-20th-century censuses showed that early exposure to filtered water was linked to increased height, higher education and income levels later in life.CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTERThe paper is part of a broader research initiative called the American Mortality Project, which examines how early-life conditions shape the modern American lifespan.TEST YOURSELF WITH OUR LATEST LIFESTYLE QUIZThe researchers exclusively analyzed historical data from American men, meaning the findings may not fully capture how early-life water filtration impacted the long-term longevity, physical growth, or cognitive scores of women from the same era.The data is limited to public health infrastructure changes across U.S. cities during a specific window in the late 19th and early 20th centuries. Because of this, the exact timeline and magnitude of the lifespan extension (3.2 months) may not directly translate to modern developing nations, rural communities, or areas with different environments. [TheTopNews] Read More.5 days ago
- Why Trump Lost
The first surprising thing about President Trump’s impending defeat in the 2026 Iran war is that he already fought and won a successful war against Iran last year. In June 2025, U.S. and Israeli airstrikes badly damaged the Iranian nuclear program in 12 days of bombardment. Exactly how badly remains controversial. But they didn’t do nothing. If Trump had quit while ahead, he could have banked his gains from last August as a solid if imperfect win.The second surprising thing about Trump’s impending defeat is that he does not seem to have cared at all about the only evident reason to resume fighting in 2026: the Iranian people’s rebellion against their brutal oppressors. Trump has never given any evidence of caring about Iranian democracy or human rights. He promised the Iranian people “Help is on the way” on January 13, but military operations did not commence until thousands were dead and the rebellion was already effectively crushed. During military operations, Trump made clear that he sought a deal with the existing regime. He made no effort to support or cooperate with Iranian dissidents before, during, or after the uprising.The third surprising thing about Trump’s impending defeat is that even he himself seems never to have understood why he went back to war against Iran. What exactly did he think he would achieve? He kept saying that he wanted to ensure that Iran never developed a nuclear weapon. He also insisted that he had effectively prevented it from doing so in August. He seemed genuinely to believe that claim. If so, why resume the fighting? If, however, those words were wrong, then why not simply hit the nuclear sites again? Why the need for this bigger war?Trump started the February 28 war for reasons of personality, not strategy. He is on his way to losing the war for the same reasons of personality.Trump is arrogant. Think how often Trump mocks his predecessors as “dumb” and praises himself as “smart.” Those predecessors, from Jimmy Carter through Ronald Reagan to Joe Biden, all had to ponder military responses to Iranian terrorism and aggression. They all ultimately decided not to wage a major war against Iranian national territory. Among the prime deterrents to action: the Strait of Hormuz problem. Trump apparently decided that a problem that was too hard for everybody else would magically disappear for him, because he is tough and growls in… [TheTopNews] Read More.5 days ago - 5 common walking mistakes that could hurt your progress, according to an expertWalking is a great way to get the body moving and clear the mind — but if you're doing it wrong, it may do more harm than good.That's according to Dr. Milica McDowell, author of the new book "Walk," a guide to getting the most out of walking.The Montana-based doctor of physical therapy, who specializes in lower extremity and orthopedics, shared in an interview with Fox News Digital how powerful walking can be.WALKING STYLE COULD BE KEY TO LONGEVITY AND INJURY COMEBACKS, ACCORDING TO EXPERTS"Walking has incredible health benefits for your wellness today and your longevity tomorrow," she said. "And it's something that's at an all-time low since the pandemic.""Walking improves every system in your body – gut, musculoskeletal, mental health, your hormones – and so it has an incredible power to help optimize how you're doing."McDowell added that walking is a "phenomenal way" to support a weight-loss journey, as it’s low-impact and low-intensity. It can also boost creativity and reduce stress.JUST 5 MINUTES OF EXERCISE COULD REDUCE HIGH BLOOD PRESSURE, STUDY FINDSWhile the health benefits of walking are evident, McDowell warned of some mistakes that could reverse progress.Escaping our phones can sometimes feel impossible, but if there’s ever a time to be on do-not-disturb, it’s during a walk, according to McDowell.Walking while scrolling is "really dangerous," she cautioned, as you're less aware of your surroundings and more susceptible to accidents."You could step in a pothole. You could get hit by a car. You could trip over something. You could bump into someone," she said. "Walking and scrolling is actually a bit of a public health crisis."SIMPLE DAILY ACTIVITY COULD REDUCE RISK OF LOWER BACK PAIN, STUDY FINDSScrolling also puts the neck in a downward position, making the head heavier, which changes your posture "from the top down," McDowell said. "That can be a problem if you're someone who struggles with neck pain, back pain or shoulder pain."McDowell recommends wearing a proper shoe designed specifically for walking to support the feet, promote healthy alignment and protect musculoskeletal health.The shoe should be "shaped like a foot" so that the toes have room to spread within a wide toe box, she said.Having space between each toe activates more muscles in the foot and creates a "more healthy walking gait," according to the expert.SIMPLE JAPANESE FITNESS TREND COULD ADD 7 YEARS TO LIFE EXPECTANCY, EXPERTS SAYMore than 60% of adults wear the wrong… [TheTopNews] Read More.5 days ago
- Passengers from high Ebola risk countries can enter Atlanta, Houston and D.C. ai...
Officials have increased the number of countries in Africa at risk for Ebola from three to 10. A third entry point is open for Americans traveling from certain high-risk countries back into the U.S. Holly Williams reports. [TheTopNews] Read More.6 days ago
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An investigational dementia drug may also ease alcohol withdrawal by calming the brain inflammation linked to addiction and relapse.That’s according to researchers at the University of Kentucky, who studied an experimental medication called MW150 that targets a brain inflammation pathway known as p38α MAPK.The drug, which has not yet been approved, is designed to treat mild to moderate Alzheimer’s disease.ALCOHOL DEATHS HAVE MORE THAN DOUBLED IN RECENT YEARS, ESPECIALLY AMONG WOMENScientists believe neuroinflammation may contribute to relapse risk and long-term neurological damage in people with alcohol use disorder.In laboratory and animal-model experiments, MW150 was found to reduce certain inflammatory markers during alcohol withdrawal.The work, which was published in the journal Alcohol, came from the University of Kentucky’s Sanders-Brown Center on Aging, led by neuroinflammation researcher Linda Van Eldik.ALCOHOL POSES THESE 8 RISKS TO OLDER ADULTS, EXPERTS WARNCaleb Bailey, PhD, co-author of the study and a researcher in Van Eldik’s lab, said the study provides "biological plausibility" that MW150 could mitigate neuroinflammation arising from alcohol withdrawal.Alcohol use disorder is difficult to treat because of high relapse rates, especially during withdrawal, according to Bailey."If follow-up experiments reveal similar anti-inflammatory effects of MW150 in animal models of alcohol use disorder, it would provide a strong rationale for development of MW150 as a treatment for those struggling with chronic alcohol relapse due to alcohol withdrawal," he told Fox News Digital.'I"M A NEUROSURGEON — HERE'S WHAT ALCOHOL DOES TO THE BODY'MW150, along with a related drug called Neflamapimod, is already being investigated in clinical trials as a potential therapy for dementia and other neurodegenerative conditions, the researchers noted."That gives this work added significance," Bailey said. "Because these compounds are already further along in development for other neurological diseases, it raises the possibility that they could someday be repurposed more efficiently for alcohol-related conditions if future studies continue to show promise."CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTERThere were some important caveats of the research, including that it was conducted in cell culture and animal models."Because they are ‘dish’-based models, they provide limited information regarding what happens in the full organism – or even the full brain for that matter," Bailey said."A series of follow-up studies in living animals is required to more fully understand how future MW150 treatment in alcohol use and withdrawal affects systemic health and/or alcohol consumption."CLICK HERE FOR MORE HEALTH STORIESDr. Amy Swift, deputy chief medical officer at Silver Hill Hospital… [TheTopNews] Read More.
4 days ago
Drinking filtered water may extend a person's life by several months, according to a new study.The research, published in the American Journal of Health Economics, reveals that being exposed to water filtration systems early in life can significantly increase longevity. By analyzing public health infrastructure shifts from the early 20th century, researchers found that city water filtration alone increased the lifespan of older American men by an average of 3.2 months.UPGRADE YOUR TAP WITH THESE COUNTERTOP REVERSE OSMOSIS SYSTEMS"While water quality has improved in many areas, this study shows the real impacts to communities without access to safe water, both in the U.S. and globally," co-author Jason Fletcher, a professor at the University of Wisconsin–Madison, said in a press release."The consequences on human health are significant."The team analyzed data from the Social Security Administration’s Death Master Files. They tracked death records for American men born between 1975 and 2005, mapping each individual’s year and city of birth to historical water filtration records.WHERE YOU LIVE COULD SHAPE YOUR RISK OF CANCER MORTALITY, STUDY SUGGESTSBy connecting early-life environments to late-life outcomes, the researchers isolated the lifelong impact of clean water.CLICK HERE FOR MORE HEALTH STORIESBeyond adding months to a person's life, the study suggests that clean water in childhood sets off a positive chain reaction for socioeconomic and physical development.Additional data from mid-20th-century censuses showed that early exposure to filtered water was linked to increased height, higher education and income levels later in life.CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTERThe paper is part of a broader research initiative called the American Mortality Project, which examines how early-life conditions shape the modern American lifespan.TEST YOURSELF WITH OUR LATEST LIFESTYLE QUIZThe researchers exclusively analyzed historical data from American men, meaning the findings may not fully capture how early-life water filtration impacted the long-term longevity, physical growth, or cognitive scores of women from the same era.The data is limited to public health infrastructure changes across U.S. cities during a specific window in the late 19th and early 20th centuries. Because of this, the exact timeline and magnitude of the lifespan extension (3.2 months) may not directly translate to modern developing nations, rural communities, or areas with different environments. [TheTopNews] Read More.
5 days ago
The first surprising thing about President Trump’s impending defeat in the 2026 Iran war is that he already fought and won a successful war against Iran last year. In June 2025, U.S. and Israeli airstrikes badly damaged the Iranian nuclear program in 12 days of bombardment. Exactly how badly remains controversial. But they didn’t do nothing. If Trump had quit while ahead, he could have banked his gains from last August as a solid if imperfect win.The second surprising thing about Trump’s impending defeat is that he does not seem to have cared at all about the only evident reason to resume fighting in 2026: the Iranian people’s rebellion against their brutal oppressors. Trump has never given any evidence of caring about Iranian democracy or human rights. He promised the Iranian people “Help is on the way” on January 13, but military operations did not commence until thousands were dead and the rebellion was already effectively crushed. During military operations, Trump made clear that he sought a deal with the existing regime. He made no effort to support or cooperate with Iranian dissidents before, during, or after the uprising.The third surprising thing about Trump’s impending defeat is that even he himself seems never to have understood why he went back to war against Iran. What exactly did he think he would achieve? He kept saying that he wanted to ensure that Iran never developed a nuclear weapon. He also insisted that he had effectively prevented it from doing so in August. He seemed genuinely to believe that claim. If so, why resume the fighting? If, however, those words were wrong, then why not simply hit the nuclear sites again? Why the need for this bigger war?Trump started the February 28 war for reasons of personality, not strategy. He is on his way to losing the war for the same reasons of personality.Trump is arrogant. Think how often Trump mocks his predecessors as “dumb” and praises himself as “smart.” Those predecessors, from Jimmy Carter through Ronald Reagan to Joe Biden, all had to ponder military responses to Iranian terrorism and aggression. They all ultimately decided not to wage a major war against Iranian national territory. Among the prime deterrents to action: the Strait of Hormuz problem. Trump apparently decided that a problem that was too hard for everybody else would magically disappear for him, because he is tough and growls in… [TheTopNews] Read More.
5 days ago
Walking is a great way to get the body moving and clear the mind — but if you're doing it wrong, it may do more harm than good.That's according to Dr. Milica McDowell, author of the new book "Walk," a guide to getting the most out of walking.The Montana-based doctor of physical therapy, who specializes in lower extremity and orthopedics, shared in an interview with Fox News Digital how powerful walking can be.WALKING STYLE COULD BE KEY TO LONGEVITY AND INJURY COMEBACKS, ACCORDING TO EXPERTS"Walking has incredible health benefits for your wellness today and your longevity tomorrow," she said. "And it's something that's at an all-time low since the pandemic.""Walking improves every system in your body – gut, musculoskeletal, mental health, your hormones – and so it has an incredible power to help optimize how you're doing."McDowell added that walking is a "phenomenal way" to support a weight-loss journey, as it’s low-impact and low-intensity. It can also boost creativity and reduce stress.JUST 5 MINUTES OF EXERCISE COULD REDUCE HIGH BLOOD PRESSURE, STUDY FINDSWhile the health benefits of walking are evident, McDowell warned of some mistakes that could reverse progress.Escaping our phones can sometimes feel impossible, but if there’s ever a time to be on do-not-disturb, it’s during a walk, according to McDowell.Walking while scrolling is "really dangerous," she cautioned, as you're less aware of your surroundings and more susceptible to accidents."You could step in a pothole. You could get hit by a car. You could trip over something. You could bump into someone," she said. "Walking and scrolling is actually a bit of a public health crisis."SIMPLE DAILY ACTIVITY COULD REDUCE RISK OF LOWER BACK PAIN, STUDY FINDSScrolling also puts the neck in a downward position, making the head heavier, which changes your posture "from the top down," McDowell said. "That can be a problem if you're someone who struggles with neck pain, back pain or shoulder pain."McDowell recommends wearing a proper shoe designed specifically for walking to support the feet, promote healthy alignment and protect musculoskeletal health.The shoe should be "shaped like a foot" so that the toes have room to spread within a wide toe box, she said.Having space between each toe activates more muscles in the foot and creates a "more healthy walking gait," according to the expert.SIMPLE JAPANESE FITNESS TREND COULD ADD 7 YEARS TO LIFE EXPECTANCY, EXPERTS SAYMore than 60% of adults wear the wrong… [TheTopNews] Read More.
5 days ago
Officials have increased the number of countries in Africa at risk for Ebola from three to 10. A third entry point is open for Americans traveling from certain high-risk countries back into the U.S. Holly Williams reports. [TheTopNews] Read More.
6 days ago
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