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- So You Want to Negotiate with Iran …
President Donald Trump recently dismissed claims he’s anxious to end the Iran war, insisting on Truth Social that he’s “possibly the least pressured person ever to be in this position” and has “all the time in the World.” If only. Trump and his aides could use some more time to think through what they want to accomplish in discussions with Tehran’s Islamist regime. The administration’s preparations for launching the war were … not great, and its negotiating efforts so far have underwhelmed. Ending the war — and keeping it ended — is almost certain to prove more complicated than Trump aides suspect. The administration has a number of fundamental questions to sort through, people who have dealt with Tehran in the past tell me. That won’t be easy given the president’s rhetorical waffling. “The details are incredibly important,” said Michael Singh, a former George W. Bush administration official who dealt with the Middle East. “Each new administration has to learn those details the hard way. The Iranians on other hand are often the same or similar teams who have negotiated these terms with multiple American administrations. You may receive what you think is a concession by the Iranians, but when you delve into it, it’s a concession from you to Iran.” I’m still not convinced Trump is ready to genuinely commit to diplomacy with Iran, despite the ongoing ceasefire. He loves using military force and knows that Iran remains the weaker side, even as both the U.S. and Iran wrestle over the fate of the Strait of Hormuz. But at some point, the global economic fallout that is hurting both Americans’ wallets and the country's reputation may force Trump to the negotiating table. If he decides to take a serious shot at talks to end the war, the first critical question Trump needs to answer is: Is he prepared to agree to a deal that ultimately leaves the Islamist regime in place? This is anathema to many Iranians who want an end to a regime that has long brutalized them. It could be intolerable for Israel and some Arab states who view Tehran as the root of many Middle East ills. Despite Trump’s occasional specious claims that he’s already changed the regime, it's clear the U.S.-Israel military attacks have failed to dislodge the Islamist system. Iranian citizens didn’t stage an uprising amid the bombing. And given Iran’s demonstrated willingness to… [TheTopNews] Read More.6 days ago - Your daily coffee habit may be quietly reshaping your gut and mood, study finds
Coffee may do more than keep you going: It could have a noticeable impact on your digestive health, even if you drink decaf.Researchers from APC Microbiome Ireland found that habitual coffee consumption alters the trillions of microbes living in the digestive tract, creating a chemical feedback loop that directly influences mood, stress levels and cognitive sharpness.The study followed 62 participants to determine how coffee interacts with the microbiome. The group included 31 coffee drinkers and 31 non-coffee drinkers who went through a series of psychological tests and kept detailed journals about their diet and coffee consumption.YOUR DAILY DIET SODA COULD BE AGING YOUR BRAIN FASTER THAN YOU THINK, STUDY FINDSThe researchers defined "coffee drinkers" as those consuming three to five cups daily, a range the European Food Safety Authority deems safe and moderate.After people stopped drinking coffee for two weeks and then started drinking it again, the bacteria in their digestive systems behaved differently than the non-drinkers, according to a press release."Coffee is more than just caffeine," study author John Cryan, principal investigator at APC Microbiome Ireland, said in a statement."It’s a complex dietary factor that interacts with our gut microbes, our metabolism and even our emotional well-being."COMMON SWEETENER MAY TRIGGER FAT BUILDUP IN WAYS EXPERTS DIDN’T EXPECTThe coffee drinkers were found to have higher levels of specific beneficial bacteria, such as Eggertella and Cryptobacterium curtum.These microbes play a vital role in releasing gastric acids and creating bile, both of which help the body eliminate harmful bacteria and manage inflammation, the researchers noted.Both caffeinated and decaf drinkers reported lower levels of perceived stress, depression and impulsivity. This suggests that the non-caffeine components of coffee, like polyphenols and antioxidants, are doing the heavy lifting for mental health.CLICK HERE FOR MORE HEALTH STORIESHowever, the two types of brew offer different perks. Caffeinated coffee was specifically linked to reduced anxiety and better focus, while decaf was shown to lead to significant improvements in learning and episodic memory.CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTERResearchers believe these cognitive gains in decaf drinkers may be tied to better sleep quality and increased physical activity.The study’s findings are limited by a small sample size, which may not accurately represent the diverse microbiome profiles found across different global populations.TEST YOURSELF WITH OUR LATEST LIFESTYLE QUIZBecause the research relied heavily on self-reported data regarding participants' coffee habits and mood levels, the results are subject to memory errors… [TheTopNews] Read More.7 days ago - Highly contagious stomach bug surges in US as some groups face severe effects→ Highly contagious stomach bug spreads fast, hitting certain patients hardest→ Woman's longtime vaping habit leads to terminal lung cancer→ Your favorite snacks could be quietly wrecking your knees, research suggests→ Plastic surgeon Dr. Sheila Nazarian speaks about the risks of traveling to other countries for plastic surgery procedures→ Natural hormone may reduce obesity without cutting calories→ Common sweetener may trigger fat buildup in ways experts didn’t expect→ Common eating habit may trigger premature immune system aging→ 'Nonnamaxxing' trend may improve mental and physical health→ Psychedelic therapy may be coming to your doctor's office as questions swirl→ Intermittent fasting’s real benefit may come after you start eating againCLICK HERE FOR MORE HEALTH STORIES [TheTopNews] Read More.7 days ago
- Auddia Announces Pricing of $12 Million Public Offering
Auddia Inc. (NASDAQ: AUUD) (NASDAQ: AUUDW) (“Auddia” or… [TheTopNews] Read More.7 days ago - Why is this game only legal across Australia one day a year?
Two-up is a coin toss betting game that was played by Australian soldiers during World War One - it’s now only legal across Australia on 25 April. [TheTopNews] Read More.7 days ago - First-ever gene therapy for hearing loss gets FDA approval: ‘Groundbreakin...A new therapy for genetic hearing loss has just been approved by the Food and Drug Administration (FDA).The treatment, Otarmeni (lunsotogene parvec-cwha), is the first-ever dual adeno-associated virus (AAV) vector-based gene therapy, meaning it uses two harmless viruses to deliver the therapy into cells.In an FDA news release, the agency called the therapy "groundbreaking," noting its potential to treat both pediatric and adult patients with "severe to profound" hearing loss linked to the OTOF gene.CLICK HERE FOR MORE HEALTH STORIESPositive results from drug trials were published in The New England Journal of Medicine in 2025, confirming that the gene therapy "improved hearing in patients with OTOF-related deafness, enabling natural acoustic hearing and normalizing hearing sensitivity in three of 12 treated patients."The FDA approval marks the first disease-modifying treatment for OTOF-related deafness.This is the sixth drug approval under the FDA commissioner’s National Priority Voucher (CNPV) pilot program and the first gene therapy to be approved through the initiative, according to the announcement.CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER"Today’s approval is a significant milestone in the treatment of genetic hearing loss," FDA Commissioner Marty Makary said in a statement.TEST YOURSELF WITH OUR LATEST LIFESTYLE QUIZ"Through the National Priority Voucher pilot program, the agency is accelerating therapies for rare diseases with unmet medical needs while proving we can successfully review even the most complex submissions — such as novel dual-vector gene therapies and combination products requiring coordination across multiple offices and centers — in significantly shortened time frames."Otarmeni is administered surgically as a one-time treatment, using a needle and a tiny tube to deliver the medicine directly into the inner ear (the cochlea) in both ears.The therapy works by delivering a healthy copy of the OTOF gene to key cells in the inner ear, helping to restore the protein otoferlin so auditory signals can be sent to the brain, according to the FDA.The treatment is intended for patients with preserved outer hair cell function and for those with no prior cochlear implant in the same ear. Side effects may include middle ear infection, nausea, dizziness and procedural pain.The FDA will host a public meeting June 4 to discuss program implementation, eligibility criteria and other processes for distribution, according to the announcement. [TheTopNews] Read More.7 days ago
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